Neutrophils (polymorphonuclear leucocytes ) are the principal cells
of the host defense system. Consequently, if periodontal pathogen –
derived substances in the gingival crevice signifi- cantly inhibit their
function, they could shift the bacterial – host balance in favour of
the bacteria. The aim of investigation was to determine if the ammonium
ions (periodontal pathogens produce substantial amounts ) affects the
main neutrofils oxidative function – reactive oxygen species generation
measured by luminol and lucigene– dependent chemiluminescence. Our
results show that ammonium ions both in the group of non-periodontally
diseased persons and in periodontitis patients have significant
inhibitive effect on luminol- and lucigene-dependent chemiluminescence,
which de- pends on NH4Cl concentration (5 mM, 10 mM, 25 mM, 50 mM), i.e.
inhibitive effect increases with increasing concentration of NH4Cl . It
shows that the presence of ammonia in the gingival crevice may increase
the risk of development of periodontal disease.
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